ISSN: 1598-3579
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IJIE, vol. 34, no. 2, pp.32-37, 2017


Comparative study on bone regeneration between silk mat incorporated 4-hexylresorcinol and collagen membrane

Hyun Seok1, You-Young Jo2, HaeYong Kweon2, Dong-Heon Baek3, Seong-Gon Kim4

Affiliation: Seong-Gon Kim, Dept oral Maxillofac Surg, Gangneung-wonju Nat Univ

Abstract: The purpose of this study was (1) to demonstrate the anti-microbial properties of 4-hexylresorcinol (4HR) loaded silk mat and (2) comparison of bone formation between 4HR incorporated silk mat and collagen membrane. Anti-microbial properties of 4HR incorporated silk mat was done after sterilization of silk mat (autoclaving and ethylene oxide gas). For the evaluation of bone formation, bilateral bony defects (size: 8 mm) were prepared in the parietal bone of the rabbits (n=10). 4HR incorporated silk mat (size: 10 x 10 mm) was applied on the right defect. For the comparative purpose, the same size of commercial collagen membrane was applied on the left defect. The anti-microbial properties of 4HR incorporated silk mat were maintained after sterilization process. When compared bone mineral density and bone volume, there was no statistically significant difference between groups at 4 weeks and 8 weeks after operation (p>0.05). In conclusion, 4HR incorporated silk mat could be autoclaved without concern of anti-microbial properties loss. In addition, 4HR incorporated silk mat showed similar bone regeneration to collagen membrane. Therefore, 4HR incorporated silk mat might be considered for the application of open membrane technique.

Keyword: silk fibroin, 4-hexylresorcinol, sterilization, membrane


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